RNA Details
Disease Name
endomyocardial fibrosis
Tissue
heart
RNA Symbol
mir-7-1
RNA ID
RNA Type
miRNA
Alteration Pattern
up regulation
Species
mus musculus
Detection Methods
PCR; immunohistochemistry etc.
Target
SP1;PARP1
Pathway
NA
PubMed ID
Title
MiR-7a/b attenuates post-myocardial infarction remodeling and protects H9c2 cardiomyoblast against hypoxia-induced apoptosis involving Sp1 and PARP-1
Year
2016
Function
"miR-7a/b overexpression suppressed specific protein 1 (SP1) and poly polymerase expression both in vivo and in vitro, and a luciferase reporter activity assay showed that miR-7a/b could directly bind to SP1,miR-7a/b as protectors of cardiac remodeling and hypoxia-induced injury in h9c2 cardiomyoblasts involving SP1."